Simpsons Season 6, Episode 20: Two Dozen and One Greyhounds

Santa's Little Helper falls in love with a female greyhound, who eventually gives birth to 25 puppies. The puppies prove troublesome and Homer and Marge decide to give them away. They have several offers, but the puppies do not want to be split up, leading to Mr. Burns stealing them. Burns is seemingly caring for the puppies, but reveals that he plans to make a tuxedo out of them, and only keep one.