Simpsons Season 19, Episode 9: Eternal Moonshine of the Simpson Mind

Homer wakes up in the snow with no memory from the night before, and Moe informs him he drank a "Forget-Me-Shot", a drink powerful enough to rid the previous 24 hours from a user's mind. With his family missing, Chief Wiggum and Ned Flanders tell him of a domestic disturbance from the night before, prompting Homer to worry he may have done something awful and tries to regain his memories with help from Professor Frink.